Use of Oxyma as pH modulatory agent to be used in the prevention of base-driven side reactions and its effect on 2-chlorotrityl chloride resin.

نویسندگان

  • Ramon Subirós-Funosas
  • Ayman El-Faham
  • Fernando Albericio
چکیده

The presence of low pKa N-hydroxylamines is beneficial in peptide chemistry as they reduce some base-mediated side reactions. Here we evaluated the applicability and buffering capacity of Ethyl 2-cyano-2-(hydroxyimino) acetate (Oxyma) in the prevention of aspartimide/piperidide formation and Pro-based overcoupling and compared it with the performance of HOBt and HOAt. In addition, the compatibility of these additives with the highly acid-labile 2-chlorotrityl chloride resin is examined.

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عنوان ژورنال:
  • Biopolymers

دوره 98 2  شماره 

صفحات  -

تاریخ انتشار 2012